EASAC is made up of 25 national science academies, 23 national science academies in the EU member states ( Cyprus, Luxembourg and Malta do not have national science academies) and, to provide a complementary Europe-wide perspective, the Academia Europaea and ALLEA
The EASAC Council consists of 25 individuals (see below) nominated by the national academies The 25 members of Council are empowered to make all decisions necessary to the running of EASAC without referring back to their nominating bodies.
The Chairman of EASAC is Professor Volker ter Meulen of the the German Academy of Sciences Leopoldina; the Vice-Chairmen are Professor Brian Heap of the Academia Europaea, Professor Sven Kullander of the Royal Swedish Academy of Sciences and Professor Jos van der Meer of the Royal Netherlands Academy of Arts and Sciences. These four constitute the Bureau, which is responsible for taking operational decisions between the six-monthly meetings of the Council. The secretariat is based at the Royal Society.
| Member | Discipline | Nominating body and position held |
| Professor Manuel Ramon Llamas | Hydrology | Secretary General, Institute of Spain |
| Professor Jüri Engelbrecht | Mechanics | President, ALLEA |
| Professor Leo Mõtus | Computer science | Secretary General, Estonian Academy of Sciences |
| Professor Lorna Casselton | Micro-biology | Foreign Secretary, Royal Society |
| Professor Jørgen Kjems | Condensed matter physics | Royal Danish Academy of Sciences and Letters |
| Professor Peter Schuster | Theoretical chemistry | President, Austrian Academy of Sciences |
| Professor Slawomir Majewski | Dermatology, allergology, oncology, immunology | Vice-Chairman, Polish Academy of Sciences |
| Professor Sven Kullander (Vice-chairman) | Nuclear physics | Vice-President, Royal Swedish Academy of Sciences |
| Professor Nicolaos Matsaniotis | Paediatrics, immunology | Secretary General, Academy of Athens |
| Professor Jan Palouš | Astronomy | President of the Council for International Affairs, Academy of Sciences of the Czech Republic |
| Professor Armando Pombeiro | Chemistry | Secretary General, Academia das Ciencias de Lisboa |
| Professor Guy Laval | Physics | Foreign Secretary, Académie des Sciences |
| Professor Olavi Nevanlinna | Mathematics | President, Delegation of Finnish Academies of Science and Letters |
| Professor Zenonas Rokus Rudzikas | Theoretical physics | President, Lithuanian Academy of Sciences |
| Professor Nikola Sabotinov | Physics | President, Bulgarian Academy of Sciences |
| Professor Nic Schamp | Organic chemistry | Secretary, Royal Flemish Academy of Sciences, Letters and Fine Arts of Belgium |
| Professor Andrejs Silins | Physics | Secretary General, Latvian Academy of Sciences |
| Professor Jan Slezak | Physiology | Vice President, Slovak Academy of Sciences |
| Professor David Spearman | Mathematics | Former President, Royal Irish Academy |
| Sir Brian Heap (Vice-Chairman) | Biological science | Chairman of Trustees, Academia Europaea |
| Professor Volker ter Meulen (Chairman) | Immunology | President, Leopoldina Academy |
| Professor Sergio Carrà | Physics | Accademia Nazionale dei Lincei |
| Professor József Pálinkás | Atomic physics | President, Hungarian Academy of Sciences |
| Professor Jos van der Meer (Vice-Chairman) | Medicine | Vice-President, Royal Netherlands Academy of Arts and Sciences |
| Professor Boštjan Zekš | Biophysics | Former President, Slovenian Academy of Sciences and Arts |
